Live Attenuated Indigenous CSF Cell Culture Vaccine (IVRI-CSF-BS)
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Background:
Classical swine fever (CSF) is the most important disease of pigs causing 100% mortality. In India, the disease is controlled by a lapinized CSF vaccine (Weybridge strain, UK) produced by killing large numbers of rabbits. To avoid this, we had earlier developed a cell culture CSF vaccine using the lapinized vaccine virus. This vaccine is obtained from a foreign strain, does not have export potential. To overcome this, we developed a new CSF cell culture vaccine using an Indian field isolate for the first time in India.
Technology Details:
• This is a cell culture vaccine for classical swine fever (CSF) developed using an Indian field isolate. This vaccine, being from a virus of Indian origin, has huge export potential.
• The most important feature of the vaccine is its very high titre (1x109.5 TCID50/ml) which has not yet been reported elsewhere for any CSF virus.
• Due to its high titre, a large number of doses (60 lakhs approx.) can be produced easily from only one 75 cm² tissue culture flask. And the country’s yearly requirement of 22 million doses can be prepared in just four 75cm² tissue culture flasks.
• This high titre vaccine would be the most economical CSF cell culture vaccine costing around less than Rs 2/- per dose as against Rs 15-25/- of lapinized CSF vaccine.
• The vaccine has been extensively tested for safety and potency and has been found to afford 100% protection.
• The vaccine has been found to induce protective immunity from day 14 of the vaccination till 18 months.